Intraepithelial Neoplasia of Breast
نویسندگان
چکیده
The early proliferative lesions of the breast have taken on greater significance as a result of mammographic screening and the use of even more sensitive imaging technologies. The intraductal proliferative lesions of the breast are a group of cytologically and architecturally diverse proliferations, typically originating from the terminal duct-lobular unit and confined to the mammary duct-lobular system. In this chapter we considere the most important of these lesions, lobular carcinoma in situ and ductal carcinoma in situ.
منابع مشابه
Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions
Background: Cervical intraepithelial neoplasia (CIN) is a premalignant lesion capable of progressing to cervical cancer. Despite the existing well-defined criteria, the histomorphologic diagnosis is subject to high rates of discordance among pathologists. The aim of this study was to evaluate Ki-67 (MIB-1), CK17 and p16 INK4a (p16) markers by immunohistochemical methods in differentiating CIN f...
متن کامل'Ductal carcinoma in situ of the breast' -- is it time to replace this term by 'ductal intraepithelial neoplasia of the breast'?
sists, given the wide geographic variations in practice standards. This is especially true regarding the use of radiation therapy, in particular for patients with small, low-grade DCIS. The use of radiation therapy in these patients will interfere with any future uses of radiation therapy if and when they develop a true mammary carcinoma. On the other hand, if the designation of ‘carcinoma’ wer...
متن کاملUtility of P16/INK4a and Ki-67 in Preneoplasticand Neoplastic Lesions of Cervix
Background and Objective: The currentstudy aimed at investigating the histomorphological spectrum of cervical intraepithelial and invasive lesions assessing the diagnostic significance of P16/INK4a and Ki-67 in such lesions, andcorrelatingP16/INK4a and Ki-67 immunoexpression with histologic type and grade.Methods: A total of 60 cases were selectedcomprisi...
متن کاملPrevalence Of Human Papilloma Virus Among Women With Cervical Intraepithelial Neoplasia III And Invasive Cervical Cancer From 2001 To 2006 In Bandarabas
Background and Objective: To estimate the risk of human papilloma virus (HPV) infection for cervical malignancies, we conducted a case-control study in southern Iran (Hormozgan province). Materials and Methods: For this purpose,52 paraffin embedded blocks with exact diagnosis of cervical carcinoma(50 carcinomas and 2 carcinomas in situ) from 2001 to 2006 and 52 praffin embedded blocks of ce...
متن کاملA Study of Matrix Metalloproteinase 9 and CD31 Expression through Immunohistochemistry in Invasive Breast Cancer
Background & Aims: This study was performed to investigate possible relationships between the manifestation of stromal cells (fibroblasts and/or myofibroblasts) by focusing on expression of their matrix metalloproteinase 9 (MMP9) and possible angiogenesis based on CD31 and CD34 antigen expression during the various steps of hyperplastic changes to precancerousstate and invasive breast cancer. M...
متن کاملPhotodynamic Therapy for Gynecological Diseases and Breast Cancer
Photodynamic therapy (PDT) is a minimally invasive and promising new method in cancer treatment. Cytotoxic reactive oxygen species (ROS) are generated by the tissue-localized non-toxic sensitizer upon illumination and in the presence of oxygen. Thus, selective destruction of a targeted tumor may be achieved. Compared with traditional cancer treatment, PDI has advantages including higher selecti...
متن کامل